125055-79-0

Basic information

• Product Name: N-cyclopentyl-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide
• CAS NO: 125055-79-0
• Molecular Formula: C₁₅H₁₇N₃O₂
• Molecular Weight: 271.3144
• Mol File: 125055-79-0.mol
• Article Data: 2

Chemical Properties

• Density: 1.33g/cm³
• Refractive Index: 1.669
• CAS DataBase Reference: N-cyclopentyl-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclopentyl-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide(125055-79-0)
• EPA Substance Registry System: N-cyclopentyl-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide(125055-79-0)

Safety Data

• Hazardous Substances Data: 125055-79-0(Hazardous Substances Data)

Upstream product

• 1003-03-8 Cyclopentamine 
• 79-22-1 methyl chloroformate 
• 33359-68-1 7-methyl-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylic acid 

Relevant articles and documents

Nitrogen bridgehead compounds. Part 92.* Synthesis of 4-oxo-4H-pyrido[1,2-a]pyriniidine-3-carboxamides, -3-acetamides and their tetrahydro derivatives

N-Substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamides (6-45), -3-acetamides (59-61) and 1,6-dimethyl-4-oxo-1,6,7,8-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carhoxamides (63-73) were synthesized in the reaction of amines and mixed anhydrides, prepared from 4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylic acids (4), -3-acetic acids (58) and 1,6-dimethyl-4-oxo-1,6,7,8-tetrahydropyrido-[1,2-a]pyrimidine-3-carhoxylic acid (62) with methyl or ethyl chloroformate in the presence of triethylamine. Whereas the reaction of 6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-acetic acid (53) with 2-phenylethylamines in boilings xylene gave the appropriate N-substituted 3-acetamides (54) and (55), reaction of 6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-acetic acid (56) with 2-phenylethylamine afforded a pyrrolidin-5-one derivative (57). 3-Acetic hydrazides (47, 48) and (50) were prepared from ethyl 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-acetates (46) and the 6,7,8,9-tetrahydro derivative (49) with hydrazine hydrate. Both 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-acetic hydrazide (47) and 6,7,8,9-tetrahydro-3-acetic hydrazide (50) were converted to 6,7,8,9-tetrahydro-3-acetamides (51, 52) by refluxing them in ethanol over Raney Ni.