125057-07-0 Usage
Chemical class
Pyrimidine derivative
Explanation
The compound is a derivative of pyrimidine, which is a heterocyclic aromatic organic compound.
Explanation
The core structure of the compound is a 2-thioxo-2,3-dihydropyrimidin-4(1H)-one, which is a type of pyrimidine with a sulfur-oxygen double bond and two hydrogen atoms attached to the second and third positions.
Explanation
The compound contains a thioxo functional group, which is a sulfur double-bonded to an oxygen atom.
Explanation
The compound has three substituents attached to the backbone structure, which are a phenylsulfanyl group, a methyl group, and a hydroxyethoxy methyl group.
Explanation
Due to its complex structure, the compound may have biological activity and could be used in the development of pharmaceuticals. However, further research and testing are required to confirm its properties and potential uses.
Explanation
The specific properties and potential applications of 1-[(2-hydroxyethoxy)methyl]-5-methyl-6-(phenylsulfanyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one are not yet fully understood, and additional research and testing are necessary to determine its characteristics and suitability for various applications.
Backbone structure
2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Functional group
Thioxo (S=O)
Substituents
a. Phenylsulfanyl group (C6H5-S-)
b. Methyl group (-CH3)
c. Hydroxyethoxy methyl group (-CH2-O-CH2-CH2-OH)
Potential applications
Pharmaceuticals
Need for further research
Properties and potential uses
Check Digit Verification of cas no
The CAS Registry Mumber 125057-07-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,0,5 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 125057-07:
(8*1)+(7*2)+(6*5)+(5*0)+(4*5)+(3*7)+(2*0)+(1*7)=100
100 % 10 = 0
So 125057-07-0 is a valid CAS Registry Number.
125057-07-0Relevant academic research and scientific papers
Synthesis and anti-HIV activity of 2-, 3- and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)
Tanaka,Baba,Ubawawa,Takashima,Sekiya,Nitta,Shigeta,Walker,De Clercq,Miyasaka
, p. 1394 - 1399 (2007/10/02)
Several analogues of a new lead for anti-HIV-1 agents, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT), in which the C-2, N-3, or C-4 position was modified were synthesized. These involve 2-thiothymine (11), 2-thiouracil (12), 4-thiothymine (17), 4-thiouracil (18), 5-methylcytosine (27), and cytosine (28) derivatives. Preparation of N-3-substituted derivatives (29 and 30) of HEPT was also carried out. Among these analogues, compound 11 exhibited excellent activity against HIV-1 HTLV-III(B) strain with an EC50 value of 0.98 μM, which is 7-fold more potent than that of HEPT. Removal of the 5-methyl group in compound 11 results in total loss of activity. Other compounds did not show any anti-HIV-1 activity. The 4-thio derivatives 17 and 18 were found to be rather cytotoxic. When compound 11 was evaluated for its inhibitory effects on another HIV-1 strain, HTLV-III(RE), and two HIV-2 strains, LAV-2(ROD) and LAV-2(EHO), it proved equally inhibitory to HTLV-III(RF), whereas both HIV-2 strains were insensitive to the compound.
