125083-80-9 Usage
Molecular structure
A complex chemical compound with a pyrimidine ring as its core structure.
Functional groups
Contains a methyl group at the 5th position, a sulfur-containing phenyl group at the 6th position, and a hydroxyethoxy methyl group at the 1st position of the pyrimidine ring.
Molecular weight
Approximately 331.39 g/mol
Potential applications
Has potential pharmaceutical applications due to its structural features.
Biological activity
May exhibit biological activity in various contexts, but further research and testing are necessary to fully understand its properties and potential uses.
Solubility
The solubility of 1-[(2-hydroxyethoxy)methyl]-6-[(4-methoxyphenyl)sulfanyl]-5-methylpyrimidine-2,4(1H,3H)-dione in different solvents is not provided in the material, but it may vary depending on the functional groups and molecular structure.
Stability
Information about the stability of 1-[(2-hydroxyethoxy)methyl]-6-[(4-methoxyphenyl)sulfanyl]-5-methylpyrimidine-2,4(1H,3H)-dione under different conditions is not provided, but it may be influenced by factors such as temperature, pH, and exposure to light or air.
Synthesis
The synthesis method for 1-[(2-hydroxyethoxy)methyl]-6-[(4-methoxyphenyl)sulfanyl]-5-methylpyrimidine-2,4(1H,3H)-dione is not provided, but it likely involves multiple steps and the formation of various intermediates.
Purity
The purity of 1-[(2-hydroxyethoxy)methyl]-6-[(4-methoxyphenyl)sulfanyl]-5-methylpyrimidine-2,4(1H,3H)-dione is not specified, but it may be affected by the presence of impurities or by-products from the synthesis process. Further purification steps may be necessary to obtain a high-purity product.
Check Digit Verification of cas no
The CAS Registry Mumber 125083-80-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,0,8 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 125083-80:
(8*1)+(7*2)+(6*5)+(5*0)+(4*8)+(3*3)+(2*8)+(1*0)=109
109 % 10 = 9
So 125083-80-9 is a valid CAS Registry Number.
125083-80-9Relevant academic research and scientific papers
Structure-Activity Relationships of 1--6-(phenylthio)thymine Analogues: Effect of Substitutions at the C-6 Phenyl Ring and at the C-5 Position on Anti-HIV-1 Activity
Tanaka, Hiromichi,Takashima, Hideaki,Ubasawa, Masaru,Sekiya, Kouichi,Nitta, Iasei,et al.
, p. 337 - 345 (2007/10/02)
The effect of substitution on the pyrimidine moiety of 1--6-(phenylthio)thymine (HEPT) and 1--6-(phenylthio)-2-thiothymine (HEPT-S) on anti-HIV-1 activity was investigated by synthesizing a series of 5-methyl-6-(arylthio) and 5-substituted-6-(phenylthio) derivatives.Preparation of the 5-methyl-6-(arylthio) derivatives was carried out based on either LDA lithiation of 1-methyl>thymine (3) and 1-methyl>-2-thiothymine (4) followed by reaction with diaryl disulfides or an addition-elimination reaction of 1-methyl>-6-(phenylsulfinyl)thymine (31) with aromatic thiols.Preparation of the 5-substituted-6-(phenylthio) derivatives was carried out based on either C-5 lithiation of the 1-methyl>-6-(phenylthio)uracil (41) with LTMP or the LDA lithiation of 5-alkyl-1-methyl>-2-thiouracil derivatives 45-47.Substitution at the meta position of the C-6-(phenylthio) ring by the methyl group improved the original anti-HIV-1 activity of HEPT, and introduction of two m-methyl groups to the phenylthio ring further potentiated the activity -1-thymine (28), 0.26 μM; 6--1--2-thiothymine (30), 0.22 μM>.When the 5-methyl group was replaced by an ethyl or an isopropyl group, the anti-HIV-1 activity of HEPT was also improved remarkably -6-(phenylthio)-2-thiouracil (48), 0.11 μM; 5-isopropyl-1--6-(phenylthio)-2-thiouracil (50), 0.059 μM; 5-ethyl-1--6-(phenylthio)-2-thiouracil (54), 0.12 μM; 5-isopropyl-1--6-(phenylthio)-2-thiouracil (56), 0.063 μM>. 6--5-ethyl-1-thymine derivatives 51 and 57 and 6--5-isopropyl-1-thymine derivatives 52 and 58 inhibited the replication of HIV-1 in the nanomolar concentration range.
