1250832-26-8Relevant articles and documents
Synthesis and Suzuki-Miyaura reactions of 5-halo-3,4-dihydropyrimidin-2(1H) -ones
Zych, Andrew J.,Wang, Hong-Jun,Sakwa, Samuel A.
experimental part, p. 5103 - 5105 (2010/11/16)
A novel synthesis of 6-methyl-4-phenyl-5-substituted-3,4-dihydropyrimidin- 2(1H)-ones from 6-methyl-4-phenyl-5-halo-3,4-dihydropyrimidin-2(1H)-ones via the Suzuki-Miyaura reaction is reported. These previously unknown heterocyclic halides are easily prepared using the Biginelli multicomponent reaction followed by halodecarboxylation. The effect of varied substitution at the C-4 position on the cross-coupling reaction is also examined.