1250870-01-9

Basic information

• Product Name: C₁₈H₁₈ClNO₃
• CAS NO: 1250870-01-9
• Molecular Weight: 331.799
• Mol File: 1250870-01-9.mol

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₈ClNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₈ClNO₃(1250870-01-9)
• EPA Substance Registry System: C₁₈H₁₈ClNO₃(1250870-01-9)

Safety Data

• Hazardous Substances Data: 1250870-01-9(Hazardous Substances Data)

Upstream product

• 79-46-9 2-nitropropane 
• 144017-77-6 1-(2-chloro-phenyl)-3-phenyl-2-propen-1-one 

Relevant articles and documents

Enantioselective Michael Addition of 2-Nitropropane to Substituted Chalcones and Chalcone Analogues Catalyzed by Chiral Crown Ethers Incorporating an α-D-Glucose or an α-D-Mannose Unit

The chiral monoaza-15-crown-5 lariat ethers annellated to methyl-4,6-O-benzylidene-α-D-glucopyranoside-(1) or -mannopyranoside (2) used as phase transfer catalysts in the Michael addition of 2-nitropropane to substituted chalcones and chalcone analogues resulted in a significant asymmetric induction. The type of substituent on the chalcone molecule was found to have a significant influence on both the chemical yield and the enantioselectivity of the reaction: 24 novel chiral Michael adducts were prepared in 14-68% ee. These ee values were somewhat lower than that experienced in the case of the unsubstituted chalcone (85% ee). In the series of chalcone analogues*The 1-naphthyl Michael adduct was formed in 87% ee. Using glucose-based crown ether 1, Formation of the (+)-enantiomers was preferred, while applying mannose-based 2 as the catalyst, the (-)-enantiomers were in excess.