1251006-64-0

Basic information

• Product Name: 3-Piperidin-4-yl-azetidine-1-carboxylic acid tert-butyl ester
• Synonyms: 3-Piperidin-4-yl-azetidine-1-carboxylic acid tert-butyl ester;tert-butyl 3-(piperidin-4-yl)-azetidine-1-carboxylate;1-Boc-3-(4-piperidinyl)azetidine;tert-Butyl 3-(piperidin-4-yl)
• CAS NO: 1251006-64-0
• Molecular Formula: C₁₃H₂₄N₂O₂
• Molecular Weight: 240.35
• Mol File: 1251006-64-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 328.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.066±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.34±0.10(Predicted)
• CAS DataBase Reference: 3-Piperidin-4-yl-azetidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidin-4-yl-azetidine-1-carboxylic acid tert-butyl ester(1251006-64-0)
• EPA Substance Registry System: 3-Piperidin-4-yl-azetidine-1-carboxylic acid tert-butyl ester(1251006-64-0)

Safety Data

• Hazardous Substances Data: 1251006-64-0(Hazardous Substances Data)

Usage

General Description

3-Piperidin-4-yl-azetidine-1-carboxylic acid tert-butyl ester is a chemical compound that falls under the category of azetidines, which are four-membered nitrogen heterocyclic compounds. This specific compound has a piperidine group, which is a six-membered heterocyclic ring containing five carbon atoms and one nitrogen atom. The carboxylic acid tert-butyl ester group indicates that it contains a carboxylic acid and tert-butyl ester functional groups. 3-Piperidin-4-yl-azetidine-1-carboxylic acid tert-butyl ester is often used in chemical synthesis and research as a building block for the creation of more complex molecules due to its unique structure and reactivity.

Upstream product

• 206446-38-0 (1-(tert-butoxycarbonyl)azetidin-3-yl)zinc(II) iodide 
• 1064194-10-0 3-bromo-azetidine-1-carboxylic acid tert-butyl ester 
• 1692-15-5 4-pyridylboronic acid 
• 15854-87-2 4-iodopyridine 
• 254454-54-1 tert-butyl-3-iodoazetidine-1-carboxylate 
• 206446-42-6 tert-butyl 3-(pyridin-4-yl)azetidine-1-carboxylate 
• 1373356-62-7 tert-butyl 3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)azetidine-1-carboxylate 
• 1373356-61-6 1-benzyl-4-(1-(tert-butoxycarbonyl)azetidin-3-yl)pyridin-1-ium bromide 

Downstream Products

• 1373356-16-1 1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-indole 
• 1373356-36-5 1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-benzimidazole 
• 1373356-10-5 2-phenyl-6-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1,3-benzoxazole 

Relevant articles and documents

INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE

Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R are defined herein.