125130-99-6

Basic information

• Product Name: 3-(2-hydroxyphenyl)-3',4',5'-trimethoxyprop-2-ynophenone
• Synonyms: 3-(2-hydroxyphenyl)-3',4',5'-trimethoxyprop-2-ynophenone
• CAS NO: 125130-99-6
• Molecular Weight: 312.322
• Mol File: 125130-99-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-hydroxyphenyl)-3',4',5'-trimethoxyprop-2-ynophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxyphenyl)-3',4',5'-trimethoxyprop-2-ynophenone(125130-99-6)
• EPA Substance Registry System: 3-(2-hydroxyphenyl)-3',4',5'-trimethoxyprop-2-ynophenone(125130-99-6)

Safety Data

• Hazardous Substances Data: 125130-99-6(Hazardous Substances Data)

Upstream product

• 125130-98-5 2-(1-ethynyl)phenyl tetrahydro-2H-2-pyranyl ether 
• 5101-44-0 2-ethynyl-phenol 

Downstream Products

• 67858-30-4 2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one 

Relevant articles and documents

53. Acid-Catalyzed Cyclization Rections of Substituted Acetylenic Ketones: A New Approach for the Synthesis of 3-Halofurans, Flavones, and Styrylchromones

Acetylenic acetals of type I (Scheme 1) and acetylenic ketones of type III (Scheme 1), 37 and 38 (Scheme 7) are versatile synthetic precursors for the synthesis of various heterocycles by acid-catalyzed cyclization reactions.By this way, substituted 3-halofurans of type II and IV (Scheme 1) and flavones and styrylchromones (Scheme 7) can be synthesized in good-to-excellent yields.The high degree of regioselectivity in the synthesis of the 3-halofurans (Scheme 4) is the result of the regioselective β-addition of HX (X = Cl, Br, I) to the acetylenic aldehyde and acetylenic ketone moieties.A possible mechanism is depicted in Scheme 5.Since 3-halofurans can easily be metalated and substituted, this approach constitutes a new synthesis of highly substituted furans.