125131-00-2

Basic information

• Product Name: (E)-5-(2-hydroxyphenyl)-1-phenylpent-1-en-4-yn-3-one
• Synonyms: (E)-5-(2-hydroxyphenyl)-1-phenylpent-1-en-4-yn-3-one
• CAS NO: 125131-00-2
• Molecular Weight: 248.281
• Mol File: 125131-00-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-5-(2-hydroxyphenyl)-1-phenylpent-1-en-4-yn-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-(2-hydroxyphenyl)-1-phenylpent-1-en-4-yn-3-one(125131-00-2)
• EPA Substance Registry System: (E)-5-(2-hydroxyphenyl)-1-phenylpent-1-en-4-yn-3-one(125131-00-2)

Safety Data

• Hazardous Substances Data: 125131-00-2(Hazardous Substances Data)

Upstream product

• 125130-98-5 2-(1-ethynyl)phenyl tetrahydro-2H-2-pyranyl ether 
• 5101-44-0 2-ethynyl-phenol 

Downstream Products

• 39103-38-3 (E)-2-styrylchromone 

Relevant articles and documents

53. Acid-Catalyzed Cyclization Rections of Substituted Acetylenic Ketones: A New Approach for the Synthesis of 3-Halofurans, Flavones, and Styrylchromones

Acetylenic acetals of type I (Scheme 1) and acetylenic ketones of type III (Scheme 1), 37 and 38 (Scheme 7) are versatile synthetic precursors for the synthesis of various heterocycles by acid-catalyzed cyclization reactions.By this way, substituted 3-halofurans of type II and IV (Scheme 1) and flavones and styrylchromones (Scheme 7) can be synthesized in good-to-excellent yields.The high degree of regioselectivity in the synthesis of the 3-halofurans (Scheme 4) is the result of the regioselective β-addition of HX (X = Cl, Br, I) to the acetylenic aldehyde and acetylenic ketone moieties.A possible mechanism is depicted in Scheme 5.Since 3-halofurans can easily be metalated and substituted, this approach constitutes a new synthesis of highly substituted furans.