1251443-42-1

Basic information

• Product Name: N-(2-allyl-3,5-dimethyl-phenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(2-allyl-3,5-dimethyl-phenyl)-4-methylbenzenesulfonamide
• CAS NO: 1251443-42-1
• Molecular Weight: 315.436
• Mol File: 1251443-42-1.mol

Chemical Properties

• CAS DataBase Reference: N-(2-allyl-3,5-dimethyl-phenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-allyl-3,5-dimethyl-phenyl)-4-methylbenzenesulfonamide(1251443-42-1)
• EPA Substance Registry System: N-(2-allyl-3,5-dimethyl-phenyl)-4-methylbenzenesulfonamide(1251443-42-1)

Safety Data

• Hazardous Substances Data: 1251443-42-1(Hazardous Substances Data)

Upstream product

• 108-69-0 3,5-dimethylaminoaniline 
• 65001-45-8 N-allyl-3,5-dimethylbenzenamine 
• 65001-46-9 2-allyl-3,5-dimethylaniline 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1309578-98-0 methyl 2-(4,6-dimethyl-1-tosylindolin-2-yl)acetate 
• 1309578-60-6 C₂₀H₂₃NO₄S 
• 1309578-48-0 (E)-methyl 4-(2,4-dimethyl-6-(4-methylphenylsulfonamido)phenyl)but-2-enoate 
• 1251443-48-7 C₁₈H₂₀INO₂S 

Relevant articles and documents

Enantioselective Synthesis of 2-Bromomethyl Indolines via BINAP(S)-Catalyzed Bromoaminocyclization of Allyl Aniline

An enantioselective bromoamination of allyl aniline with N-bromosuccinimide (NBS) catalyzed by BINAP(S) (BINAP monosulfide) is described. This protocol could provide a range of chiral 2-bromomethyl indolines in good to excellent yields with up to 87% ee.

Palladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles

A novel palladium-catalyzed aminomethylamination of aminoalkenes with an aminal, functioning not only as an aminomethylation reagent but also as an oxidant, was developed. This direct and operationally simple protocol provides a fundamentally novel and unique approach toward the synthesis of 2-(2-aminoethyl)indoles and 2-(2-aminoethyl)pyrrolidines, which are important building blocks in synthetic organic chemistry. The unity of this method was highlighted by the rapid synthesis of Alosetron, a drug used for the treatment of irritable bowel syndrome.

Copper-catalyzed radical cascade cyclization for the synthesis of phosphorated indolines

A novel and convenient approach to the synthesis of various phosphorated indolines via a copper-catalyzed radical cascade cyclization reaction has been developed. The reaction employs cheap copper as the catalyst and K2S2O8 as the oxidant under mild conditions. Various alkenes and P-radical precursors are compatible with this transformation. Preliminary mechanistic studies reveal that the addition of the P-radical may initiate the reaction, and then oxidative cyclization may be achieved to afford the desired product. This journal is

Metal-ligand bifunctional activation and transfer of N-H bonds

The concept of metal-ligand bifunctionality can be employed for an efficient activation of N-H bonds by well-defined ruthenium amido complexes. An enantioselective catalytic aza-Michael reaction was developed on the basis of this process, which gives rise