1251462-52-8

Basic information

• Product Name: C₃₄H₃₃FN₆O₄S
• CAS NO: 1251462-52-8
• Molecular Weight: 640.738
• Mol File: 1251462-52-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₄H₃₃FN₆O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₃₃FN₆O₄S(1251462-52-8)
• EPA Substance Registry System: C₃₄H₃₃FN₆O₄S(1251462-52-8)

Safety Data

• Hazardous Substances Data: 1251462-52-8(Hazardous Substances Data)

Upstream product

• 1202923-32-7 3-benzyloxy-9-bromo-2-[5-(4-fluoro-benzyl)-thiazol-2-yl]-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one 
• 10166-54-8 1-methyltetrahydropyrimidin-2(1H)-one 

Downstream Products

• 1251462-34-6 C₂₇H₂₇FN₆O₄S 

Relevant articles and documents

Discovery of potent HIV integrase inhibitors active against raltegravir resistant viruses

A series of novel HIV integrase inhibitors active against rategravir resistant strains are reported. Initial SAR studies revealed that activities against wild-type virus were successfully maintained at single digit nanomolar level with a wide range of substitutions. However, inclusion of nitrogen-based cyclic substitutions was crucial for achieving potency against mutant viruses. Several compounds with excellent activities against wild-type virus as well as against the viruses with the mutations Q148H/G140S or N155H/E92Q were reported.