1251595-68-2Relevant academic research and scientific papers
Asymmetric aziridination of N-tert-butanesulfinyl imines with phenyldiazomethane via sulfur ylides
Xue, Zheng,Dee, Veronica M.,Hope-Weeks, Louisa J.,Whittlesey, Bruce R.,Mayer, Michael F.
experimental part, p. 65 - 80 (2010/08/22)
Optically active aziridines were synthesized from the reaction of chiral nonracemic N-tert-butanesulfinyl imines with benzyl-stabilized sulfur ylides, wherein the latter were generated from a rhodium-catalyzed decomposition of phenyldiazomethane (PDM) in the presence of various sulfides. In most cases, the aziridines were formed and isolated in quantitative yield and the 2,3-trans-aziridines were found to predominate over the 2,3-cis-aziridine isomers. The diastereoselectivity between the two trans-aziridines was found to vary significantly, depending upon the solvent and sulfide employed in the reaction.
