1251607-07-4Relevant academic research and scientific papers
6-Substituted imidazo[1,2-a]pyridines: Synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2
Dahan-Farkas, Nurit,Langley, Candice,Rousseau, Amanda L.,Yadav, Dharmendra B.,Davids, Hajierah,De Koning, Charles B.
experimental part, p. 4573 - 4583 (2011/11/05)
A range of 6-substituted imidazo[1,2-a]pyridines were synthesized using a multicomponent coupling reaction. Most of these compounds were found to exhibit excellent activity against the colon cancer cell lines HT-29 and Caco-2, whilst not showing significa
IMIDAZ0[1,2-A] PYRIDINE-6-CARBOXAMIDE DERIVATIVES, THEIR USE FOR THE TREATMENT OF COLON CANCER AND THEIR METHOD OF MANUFACTURE
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Page/Page column 6, (2010/11/03)
This invention relates to the manufacture of novel chemical compounds which have biological activity, particularly to novel chemical compounds that are cytotoxic against colon cancer cells and colon cancer cell lines. The manufacturing of said chemical compounds displaying anti-cancer properties employs the use of multi-component chemical reactions. The object of this invention is to manufacture and isolate analogues of imidazo[1,2-a]pyridine, namely compounds of Formula 1, which are cytotoxic against colon cancer cells, while concomitantly being relatively inactive against white blood cells. Formula 1 wherein, R is bromo, methyl, phenyl, nitro, hydrogen or an amide functional group; R1 is benzyl, 2,6-dimethylphenyl or cyclohexyl; and R2 is methoxy, benzyloxy or hydroxy.
