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1251765-07-7

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1251765-07-7 Usage

General Description

1,2-Cyclopentanediol, 3-[7-amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)- is a complex chemical compound with a long name and diverse properties. It is a cyclopentanediol derivative that contains a triazolopyrimidine ring system and an amino group, as well as a hydroxyethoxy and propylthio side chain. The compound exhibits stereochemistry at the 1st, 2nd, 3rd, and 5th positions, contributing to its unique structure and potential pharmaceutical applications. The presence of hydroxyl, amino, and thiol groups, as well as the heterocyclic ring system, suggests that this compound may have biological activity, such as binding to proteins or enzymes, and could be a potential target for drug development or research in medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 1251765-07-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,1,7,6 and 5 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1251765-07:
(9*1)+(8*2)+(7*5)+(6*1)+(5*7)+(4*6)+(3*5)+(2*0)+(1*7)=147
147 % 10 = 7
So 1251765-07-7 is a valid CAS Registry Number.

1251765-07-7Downstream Products

1251765-07-7Relevant articles and documents

HPLC method for simultaneous analysis of ticagrelor and its organic impurities and identification of two major photodegradation products

Bueno, Lívia Maronesi,Manoel, Joanna Wittckind,Giordani, Camila Ferrazza Alves,Mendez, Andreas Sebastian Loureiro,Volpato, Nadia Maria,Schapoval, Elfrides Eva Scherman,Steppe, Martin,Garcia, Cássia Virginia

, p. 22 - 29 (2017)

A simple, fast and sensitive analytical method by high-performance liquid chromatography (HPLC) was developed and validated for the simultaneous determination of ticagrelor and two synthesis impurities. The HPLC method was established using an Agilent 1200 Series equipment coupled to photodiode array detector (PDA) at 270?nm with a Zorbax Plus C8 column (150?×?4.6?mm, 5.0?μm), injection volume of 20?μL, and a constant temperature of 25?°C. The mobile phase consisted of acetonitrile: ammonium acetate 50?mM (57:43, v/v) and pH adjusted to 8.2 with ammonium hydroxide 6?M, at a flow rate of 0.7?mL/min. No interference peaks from excipients and diluent system indicated the specificity of the method. The calibration curves showed determination coefficients (r2)?>?0.99, calculated by linear regression. The limit of quantitation (LOQ) for impurities 1 and 2 were 2.0 and 0.2?μg/mL, respectively. Intra and interday relative standard deviations (RSDs) were ?2% for ticagrelor and ?6% for the impurities, proving the precision of the method. Besides, two mayor degradation products formed when sample solutions of ticagrelor were exposed to UVC radiation were elucidated and the mechanisms involved in the photolytic degradation of ticagrelor were proposed.

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