1251828-76-8

Basic information

• Product Name: benzyl 3-{8-[(Boc-amino)-methylthio-methyleneamino]-8-oxooctanamido}propanoate
• Synonyms: benzyl 3-{8-[(Boc-amino)-methylthio-methyleneamino]-8-oxooctanamido}propanoate
• CAS NO: 1251828-76-8
• Molecular Weight: 507.651
• Mol File: 1251828-76-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl 3-{8-[(Boc-amino)-methylthio-methyleneamino]-8-oxooctanamido}propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 3-{8-[(Boc-amino)-methylthio-methyleneamino]-8-oxooctanamido}propanoate(1251828-76-8)
• EPA Substance Registry System: benzyl 3-{8-[(Boc-amino)-methylthio-methyleneamino]-8-oxooctanamido}propanoate(1251828-76-8)

Safety Data

• Hazardous Substances Data: 1251828-76-8(Hazardous Substances Data)

Upstream product

• 173998-77-1 tert-butyl [amino(methylthio)methylene]carbamate 
• 1251828-50-8 8-[3-(benzyloxy)-3-oxopropylamino]-8-oxooctanoic acid 

Relevant articles and documents

NG-Acyl-argininamides as NPY Y1 receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity

NG-Acylated argininamides, covering a broad range of lipophilicity (calculated log D values: -1.8-12.5), were synthesized and investigated for NPY Y1 receptor (Y1R) antagonism, Y 1R affinity and stability in buffer (NG-deacylation, yielding BIBP 3226). Broad structural variation of substituents was tolerated. The Ki (binding) and Kb values (Y1R antagonism) varied from low nM to one-digit μM. Most of the compounds proved to be sufficiently stable at pH 7.4 over 90 min to determine reliable pharmacological data in vitro. Exceptionally high instability was detected when a succinyl moiety was attached to the guanidine, probably, due to an intramolecular cleavage mechanism.