1251852-01-3Relevant academic research and scientific papers
Synthesis and anti-inflammatory activity of 4-substituted-2,5-disubstituted indolyl azetidine-3-yl/thiazolidin-1-yl-substituted triazoles
Chandra, Trilok,Garg, Neha,Kumar, Ashok
experimental part, p. 243 - 252 (2010/08/07)
A new series of 4-[2′-(substituted phenyl)-5′-methoxy indolyl azetidine-l-yl/thiazolin-1-yl-3-(substituted phenyl)-5-mercapto-l,2,4-triazoles were designed, synthesized and tested for anti-inflammatory and analgesic activities. All compounds were screened in vitro for anti-inflammatory activity against carrageenan induced rat paw oedema and tested for their analgesic activity against phenyl quinone induced pain syndrome in mice at a dose of 50 mg/kg p.o. All the compounds of this series have been analyzed and confirmed by elemental (C, H, N) and spectral methods, i.e. I.R., 1HNMR, 13C NMR and mass spectrometry data.
