1251902-39-2Relevant academic research and scientific papers
Abnormal and direct para-trifluoroacetylation of branched alkyl phenyl ketones by magnesium-promoted reductive aromatic substitution
Maekawa, Hirofumi,Ozaki, Taro,Zulkeflee, Dayana,Murakami, Taro,Kihara, Shin,Nishiguchi, Ikuzo
, p. 401 - 404 (2012/03/11)
Magnesium-promoted reduction of branched alkyl phenyl ketones in the presence of ethyl trifluoroacetate and chlorotri-methylsilane in N,N-dimethylformamide (DMF), followed by air oxidation, and the subsequent treatment of tetrabutylammonium fluoride brought about selective and efficient formation of the corresponding aromatic para-substituted diketones possessing a tri-fluoroacetyl group in good yields through abnormal addition toward the para positions of the aromatic ketones in good yields. Georg Thieme Verlag Stuttgart · New York.
