1251920-89-4Relevant academic research and scientific papers
Microwave-assisted novel synthesis of amino-thieno[3,2-b]pyridines under solvent-free conditions
Su, Weike,Guo, Shaozheng,Hong, Zhi,Chen, Ren'Er
experimental part, p. 5718 - 5720 (2010/11/16)
In the presence of a catalytic amount of ytterbium(III) triflate and under microwave irradiation, mixtures of 2-amino-3-thiophenecarbonitriles, ketones, and silica gel afforded smoothly the corresponding amino-thieno[2,3-b]pyridine derivatives in one step. A wide variety of ketones were tested under these conditions. The reactions proceeded rapidly and afforded the desired products in good to excellent yields.
