1251923-90-6

Basic information

• Product Name: (1-Cyano-cyclobutyl)-carbamic acid tert-butyl ester
• Synonyms: (1-Cyano-cyclobutyl)-carbamic acid tert-butyl ester;Tert-Butyl N-(1-Cyanocyclobutyl)Carbamate;Tert-Butyl N-(1-Cyanocyclobutyl)Carbamate(WX683057)
• CAS NO: 1251923-90-6
• Molecular Formula: C10H16N2O2
• Molecular Weight: 196.24624
• EINECS: -0
• Mol File: 1251923-90-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (1-Cyano-cyclobutyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Cyano-cyclobutyl)-carbamic acid tert-butyl ester(1251923-90-6)
• EPA Substance Registry System: (1-Cyano-cyclobutyl)-carbamic acid tert-butyl ester(1251923-90-6)

Safety Data

• Hazardous Substances Data: 1251923-90-6(Hazardous Substances Data)

Usage

General Description

The chemical (1-Cyano-cyclobutyl)-carbamic acid tert-butyl ester, also known as tert-butyl (1-cyanocyclobutyl)carbamate, is an organic compound with the molecular formula C9H15NO2. It is a derivative of carbamic acid and is commonly used in the synthesis of pharmaceuticals and agrochemicals. This chemical is a colorless to pale yellow liquid with a slightly sweet odor. It is considered to be stable under normal conditions and has a low to moderate toxicity. (1-Cyano-cyclobutyl)-carbamic acid tert-butyl ester is used as a versatile building block in organic chemistry and is utilized in the production of various drugs and other chemical products.

Upstream product

• 22821-76-7 4-(methylsulfonyl)benzonitrile 
• 120728-10-1 1-[(tert-butoxycarbonyl)amino]cyclobutanecarboxylic acid 
• 1044756-34-4 tert-butyl N-(1-carbamoylcyclobutyl)carbamate 
• 1191-95-3 cyclobutanone 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 70780-84-6 1-aminocyclobutane-1-carbonitrile 

Relevant articles and documents

Decarboxylative Cyanation of Aliphatic Carboxylic Acids via Visible-Light Flavin Photocatalysis

An operationally simple method is disclosed for the decarboxylative cyanation of aliphatic carboxylic acids at room temperature. Riboflavin tetraacetate, which is an inexpensive organic photocatalyst, promotes the oxidation of carboxylic acids upon visible-light activation. After decarboxylation, the generated radicals are trapped by TsCN, yielding the desired nitriles without any further additive, in a redox-neutral process. Importantly, this protocol can be adapted to flow conditions.

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C

A series of dipeptide nitriles with a thienyl alanine in P2 were identified as potent and selective cathepsin C inhibitors. Incorporation of a substituted cyclopropyl moiety in P1 effectively protects these derivatives against hydrolase activity in whole blood.