125197-81-1

Basic information

• Product Name: methyl (1E)-3-(3-oxo-1-propenylthio)benzoate
• CAS NO: 125197-81-1
• Molecular Weight: 222.265
• Mol File: 125197-81-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (1E)-3-(3-oxo-1-propenylthio)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (1E)-3-(3-oxo-1-propenylthio)benzoate(125197-81-1)
• EPA Substance Registry System: methyl (1E)-3-(3-oxo-1-propenylthio)benzoate(125197-81-1)

Safety Data

• Hazardous Substances Data: 125197-81-1(Hazardous Substances Data)

Upstream product

• 624-67-9 Propargylic aldehyde 
• 72886-42-1 methyl 3-sulfanylbenzoate 

Downstream Products

• 125198-02-9 methyl (1E,3Z)-3-(1,3-pentadecadien-6-ynylthio)benzoate 
• 125197-89-9 methyl (1E,3Z,6Z)-3-(1,3,6-pentadecatrienylthio)benzoate 

Relevant articles and documents

Design, Synthesis, and 5-Lipoxygenase-Inhibiting Properties of 1-Thio-Substiuted Butadienes

The synthesis of novel 1-thio-substituted butadienes, designed as mechanism-based 5-lipoxygenase inhibitors, is described.The structure of these compounds closely resembles a proposed high-energy intermediate during the lipoxygenation of arachidonic acid.They demonstrate 5-lipoxygenase inhibition in vitro and in vivo.The most potent compound is 15a with an IC50 of μM in vitro.LTC4 release was inhibited by 80percent after intraperitoneal administration of 15c at a dose of 2 mg/kg.