1252004-20-8Relevant articles and documents
Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedl?nder reaction
Gavara, Laurent,Boisse, Thomas,Hénichart, Jean-Pierre,Da?ch, Adam,Rigo, Beno?t,Gautret, Philippe
, p. 7544 - 7561 (2010/12/25)
In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedl?nder condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.
Synthesis and bioevaluation of 22-hydroxyacuminatine analogs
Grillet, Francois,Baumlova, Barbora,Prevost, Gregoire,Constant, Jean-Francois,Chaumeron, Sophie,Bigg, Dennis C.H.,Greene, Andrew E.,Kanazawa, Alice
, p. 2143 - 2146 (2008/12/21)
A series of 22-hydroxyacuminatine analogs was prepared by using different Friedlaender condensations. Several of the new compounds were tested for antiproliferative activity on cancer cell lines and for topoisomerase I inhibitory activity.
