1252016-42-4Relevant academic research and scientific papers
Synthesis of 4-thiouracil KPGEPGPK analogues as potential TIIICBP identification tools
Pires, Viviane Silva,Da Nascimento, Sophie,Sonnet, Pascal
, p. 257 - 266 (2010)
In this paper, we described the synthesis of three octapeptides analogues which are obtained by the incorporation of photochemical 4-thiouracil (s 4U) probes selectively activables. This probe has been incorporated at the 1 and/or 3 positions in KPGEPGPK sequence since it has been demonstrated that those positions could be mutated without major anti-thrombotic activity modifications. These analogues could be used to identify a new receptor for type III collagen named Type III Collagen Binding Protein (TIIICBP).
