1252016-65-1Relevant academic research and scientific papers
Diazoacetoacetate enones for the synthesis of diverse natural product-like scaffolds
Shanahan, Charles S.,Truong, Phong,Mason, Savannah M.,Leszczynski, John S.,Doyle, Michael P.
supporting information, p. 3642 - 3645 (2013/08/23)
Diazoacetoacetate enones are a new class of Michael acceptors that enable the efficient construction of natural product-like scaffolds. Through their Michael addition reactions, including those with silyl enol ethers, indoles, pyrroles, and amines, δ-functionalized diazoacetoacetates are formed in high yield and with overall operational efficiency. Subsequent catalytic dinitrogen extrusion reactions provide access to a diverse series of natural product-like carbo- and heterocyclic ring systems in only three steps from commercial materials.
Chemoselectivity in dirhodium(II) catalyzed reactions of diazoacetoacetates prepared from α,β-unsaturated ketones
Zhang, Yu,Doyle, Michael P.
experimental part, p. 10 - 16 (2010/09/04)
α-Diazo β-keto esters from zinc triflate catalyzed Mukaiyama-Michael reactions between α,β-unsaturated ketones and α-silyloxyvinyldiazoacetates are valuable synthons for the synthesis of compounds that can be accessed through catalytic diazo decomposition
