1252021-75-2Relevant academic research and scientific papers
Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin
Hirai, Sho,Nakada, Masahisa
experimental part, p. 518 - 530 (2011/03/19)
Enantioselective divergent approaches to (-)-platencin and (-)-platensimycin have been developed. A rationally designed chiral synthetic intermediate, possessing a useful α,β-unsaturated sulfone functionality, which served as a masked ketone as well as a good Michael acceptor, was successfully prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) developed in our laboratory. Copyright
An enantioselective approach to (-)-platencin via catalytic asymmetric intramolecular cyclopropanation
Hirai, Sho,Nakada, Masahisa
scheme or table, p. 5076 - 5079 (2011/01/04)
This Letter describes an enantioselective approach to (-)-platencin. A uniquely functionalized chiral intermediate, which was prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) that we have developed, was successfully transformed to Nicolaou's intermediate in his total synthesis of (-)-platencin.
