125212-58-0Relevant academic research and scientific papers
Reagent directing group controlled organic synthesis: Total synthesis of (R,R,R,)-α-tocopherol
Rein, Christian,Demel, Peter,Outten, Robert A.,Netscher, Thomas,Breit, Bernhard
, p. 8670 - 8673 (2007)
(Chemical Equation Presented) The direct approach: The efficient use of substrate control has served as the basis for the enantioselective total synthesis of (R,R,R)-α-tocopherol. A single reagent directing group (ortho-diphenylphosphanyl benzoate, o-DPPB) served to control the stereoselectivity of a rhodium-catalyzed hydroformylation reaction and the directed allylic substitution as the fragment-coupling step (see picture).
