SPDP-PEG8-NHS ester is a versatile PEG-based molecule that features an SPDP crosslinker and an NHS ester. The SPDP crosslinker is reactive with amine and thiol groups and contains a cleavable disulfide bond, which allows for intracellular reactions due to its membrane permeability. The NHS ester, on the other hand, can react with primary amines to form stable amide bonds. The hydrophilic PEG8 linker enhances the water solubility of compounds in aqueous media, making SPDP-PEG8-NHS ester a valuable tool in various applications.
1252257-56-9
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Basic information
- Product Name: SPDP-PEG8-NHS ester
- Synonyms: SPDP-PEG8-NHS ester;SDPD-PEG8-NHS;SPDP-dPEG(R)8-NHS ester
- CAS NO:1252257-56-9
- Molecular Formula: C31H49N3O13S2
- Molecular Weight: 735.86306
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1252257-56-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: 1.29±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: -20°C
- Solubility: N/A
- PKA: 15.01±0.46(Predicted)
- CAS DataBase Reference: SPDP-PEG8-NHS ester(CAS DataBase Reference)
- NIST Chemistry Reference: SPDP-PEG8-NHS ester(1252257-56-9)
- EPA Substance Registry System: SPDP-PEG8-NHS ester(1252257-56-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1252257-56-9(Hazardous Substances Data)
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1252257-56-9 Usage
Uses
Used in Bioconjugation:SPDP-PEG8-NHS ester is used as a bioconjugation agent for the formation of stable amide bonds between primary amines. Its reactivity with amine and thiol groups makes it suitable for attaching biomolecules, such as proteins or peptides, to other molecules or surfaces.
Used in Drug Delivery Systems:
In the pharmaceutical industry, SPDP-PEG8-NHS ester is used as a component in drug delivery systems. Its ability to form stable bonds with primary amines allows for the development of targeted drug conjugates, improving the specificity and efficacy of therapeutic agents.
Used in Diagnostics:
SPDP-PEG8-NHS ester is used as a labeling agent in diagnostic applications. Its reactivity with amine and thiol groups enables the attachment of detection molecules, such as fluorescent dyes or radioisotopes, to biomolecules for various imaging and detection techniques.
Used in Material Science:
In the field of material science, SPDP-PEG8-NHS ester is used as a crosslinking agent to improve the properties of polymers and hydrogels. Its cleavable disulfide bond allows for the controlled release of encapsulated molecules or the degradation of the material under specific conditions.
Used in Cosmetics:
In the cosmetics industry, SPDP-PEG8-NHS ester is used as a stabilizing agent for the formulation of creams, lotions, and other personal care products. Its ability to form stable bonds with primary amines helps improve the texture, consistency, and shelf life of these products.
Check Digit Verification of cas no
The CAS Registry Mumber 1252257-56-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,2,2,5 and 7 respectively; the second part has 2 digits, 5 and 6 respectively.Calculate Digit Verification of CAS Registry Number 1252257-56:
(9*1)+(8*2)+(7*5)+(6*2)+(5*2)+(4*5)+(3*7)+(2*5)+(1*6)=139
139 % 10 = 9
So 1252257-56-9 is a valid CAS Registry Number.
1252257-56-9Upstream product
1252257-56-9Downstream Products
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SPDP-PEG8-NHS ester
