125250-45-5Relevant academic research and scientific papers
(Malonato)bis[sulfinylbis[methane]-S]platinum(II) compounds: Versatile synthons for a new general synthesis of antitumor symmetrical and dissymmetrical (malonato)platinum(II) complexes
Bitha, Panayota,Morton, George O.,Dunne, Theresa S.,Delos Santos, Eugenia F.,Lin, Yang-I,Boone, Steven R.,Haltiwanger, R. Curtis,Pierpont, Cortlandt G.
, p. 645 - 652 (2008/10/08)
New (malonato)platinum(II) compounds, cis-[Pt(OOCACOO)(Me2SO)2] (A = CH2, cycloalkyl), have been prepared, and their reactions with various amines have led to a new general synthesis of antitumor symmetrical and dissymmetrical (malonato)platinum(II) complexes. Reaction of trans-(-)-1,2-cyclohexanediamine (CHDA*) with the cyclobutanedicarboxylate (CBDC) complex cis-[Pt(CBDC)(Me2SO)2] has been studied in detail, and crystallographic molecular structure determinations have been carried out on the Pt(CHDA*)(Me2SO)(CBDC) intermediate and the Pt(CHDA*)(CBDC) product. Crystals of Pt(CHDA*)(Me2SO)(CBDC) grown from aqueous solution form as unstable hydrates, which rapidly lose water molecules of crystallization upon removal from the crystallization solution at room temperature. X-ray data were collected on a crystal at -100° C. The complex crystallizes in the noncentrosymmetric triclinic unit cell P1 with four independent Pt(CHDA*)(Me2SO)(CBDC) molecules and thirteen independent water molecules per unit cell. Unit cell dimensions are a = 10.998 (3) A?, b = 13.946 (5) A?, c = 15.163 (5) A?, α = 65.39 (2)°, β = 88.21 (2)°, γ = 79.64 (2)°, and V = 2078 (1) A?3. Complex molecules form as two independent hydrogen-bonded dimers, [Pt(CHDA*)(Me2SO)(CBDC)]2, with hydrogen-bonded water molecules linking the two complex units. Platinum atoms of the complex are four-coordinate, bonded to the two nitrogens of the CHDA* ligand, the sulfur atom of the DMSO ligand, and one of the carboxylate oxygen atoms of the monodentate CBDC ligand. Crystals of Pt(CHDA*)(CBDC) obtained from aqueous solution form as hydrates in the noncentrosymmetric centered monoclinic unit cell C2. Unit cell dimensions are a = 24.889 (16) A?, b = 5.382 (2) A?, c = 11.426 (4) A?, β = 106.97 (2)°, and V = 1464 (1) A?3, with one independent complex molecule and two half water molecules per asymmetric region of the unit cell. Displacement of the DMSO ligand of Pt(CHDA*)(Me2SO)(CBDC) results in chelation of the CBDC ligand in Pt(CHDA*)(CBDC). The two half water solvate molecules are hydrogen bonded to oxygen atoms of adjacent complex molecules.
