1252559-75-3Relevant academic research and scientific papers
A new series of macrolide derivatives with 4″-O-saccharide substituents
Xu, Peng,Chen, Xiao-Zhuo,Liu, Lu,Jin, Zhi-Ping,Lei, Ping-Sheng
supporting information; experimental part, p. 5527 - 5531 (2010/12/24)
A series of novel derivatives of macrolide with 4″-O-mono- or disaccharides were synthesized. The corresponding glycosyl trichloroacetimidates were used as the donors in the glycosylations. The in vitro antibacterial activities of 7a-f and 13-16 against a panel of susceptible and resistant pathogens were tested. The modification of 4″-O-mono- or disaccharides may lead to the understanding of interaction of the macrolide and the bacterial ribosome.
