1252605-72-3Relevant academic research and scientific papers
Synthesis, antitumor and antimicrobial activity of novel 1-substituted phenyl-3-[3-alkylamino(methyl)-2-thioxo-1,3,4-oxadiazol-5-yl] β-carboline derivatives
Savariz, Franciele C.,Formagio, Anelise S.N.,Barbosa, Vale?ria A.,Foglio, Mary Ann,De Carvalho, Joa?o E.,Duarte, Marta C.T.,Dias Filhoc, Benedito P.,Sarragiotto, Maria Helena
supporting information; experimental part, p. 288 - 298 (2010/09/05)
With the purpose of activity enhancement of 1-substituted phenyl-3-(2-thioxo-1,3,4-oxadiazol-5-yl) β-carbolines 1a-c, reported as potential antitumor agents in our previous study, herein we report the synthesis and antitumor activity evaluation of several novel Mannich bases 2-7(a-c), by the introduction of different alkylamino(methyl) groups in the 1,3,4-oxadiazole unity of 1a-c. The antimicrobial activities of 1a-c and of 2-7(a-c) were also evaluated. Additionally, an in silico study of the ADME properties of novel synthesized β-carboline derivatives 2-7(a-c) was performed by evaluation of their Lipinski's parameters and topological polar surface area (TPSA) and percentage of absorption (percent ABS) data.
