1252609-22-5Relevant academic research and scientific papers
Efficient synthesis of biologically interesting 3,4-diaryl-substituted succinimides and maleimides: Application of iron-catalyzed carbonylations
Prateeptongkum, Saisuree,Driller, Katrin Marie,Jackstell, Ralf,Spannenberg, Anke,Beller, Matthias
, p. 9606 - 9615 (2010)
A straightforward two-step synthesis of trans-3,4-disubstituted succin imides through a palladium-catalyzed Sonogashira reaction and an iron-catalyzed double carbonylation is described. In situ oxidative dehydrogenation gave the corresponding 3,4-diarylmaleimides. By starting from readily available aryl and hetgeroaryl halides, a variety of new analogues and derivatives of bioactive 3,4-bisindolylmaleimides are obtained in good yield and selectivity.
