125261-18-9

Usage

Molecular Structure

A chemical compound derived from pyrrole, a five-membered aromatic ring with one nitrogen atom.

Functional Groups

Contains a carboxyl group (-COOH) and an ethyl ester group (-OC2H5) attached to the 2and 5-positions of the pyrrole ring, respectively.

Substitution Pattern

A phenylmethyl group (-CH2C6H5) is attached to the 5-position of the pyrrole ring.

Synthesis

It is an ethyl ester derivative of 1H-Pyrrole-2-carboxylic acid.

Applications

Commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and biologically active molecules.

Potential Uses

Has potential applications in drug discovery and development, materials science, and chemical research.

Reactivity

Its structural features and reactivity make it a valuable intermediate in the production of novel compounds with therapeutic properties.

Upstream product

• 125261-02-1 (2-benzyl-1,3-dioxolan-2-yl)acetaldehyde 
• 125261-11-2 4-(2-Benzyl-[1,3]dioxolan-2-yl)-2-dibenzylamino-3-hydroxy-butyric acid ethyl ester 

Relevant academic research and scientific papers

Pyrrole and pyrazole DAAO inhibitors

Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: wherein R1 and R2 are independently selected from hydrogen, halo, nitro, alkyl, acyl, alkylaryl, and XYR5; or R1 and R2, taken together, form a 5, 6, 7 or 8-membered substituted or unsubstituted carbocyclic or heterocyclic group; X and Y are independently selected from O, S, NH, and (CR6R7)n; R3 is hydrogen, alkyl or M+; M is aluminum, calcium, lithium, magnesium, potassium, sodium, zinc ion or a mixture thereof; Z is N or CR4; R4 is from selected from hydrogen, halo, nitro, alkyl, alkylaryl, and XYR5; R5 is selected from aryl, substituted aryl, heteroaryl and substituted heteroaryl; R6 and R7 are independently selected from hydrogen and alkyl; n is an integer from 1 to 6; at least one of R1, R2 and R4 is other than hydrogen; and at least one of X and Y is (CR6R7)n. D-serine or cycloserine may be coadministered along with the compound of formula I.

SYNTHESIS OF 5-SUBSTITUTED ETHYL PYRROLE-2-CARBOXYLATES

A new synthesis of 5-substituted ethyl pyrrole-2-carboxylates from ethyl N,N-dibenzylglycinate and β-ketoacetals is described.