125263-58-3

Upstream product

• 30067-00-6 methyl (2RS,3RS)-2-hydroxy-3-(p-methoxyphenyl)-3-(o-nitrophenylthio)propanoate 
• 541-88-8 Chloroacetic anhydride 

Downstream Products

• 125354-93-0 (2S,3S) methyl 2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)propionate 
• 125354-94-1 methyl (2R,3R)-2-hydroxy-3-(p-methoxyphenyl)-3-(o-nitrophenylthio)propanoate 
• 125354-96-3 (2S,3S)-2-(2-Chloro-acetoxy)-3-(4-methoxy-phenyl)-3-(2-nitro-phenylsulfanyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Enzymatic hydrolysis in organic solvents for kinetic resolution of water-insoluble α-acyloxy esters with immobilized lipases

Enantioselective hydrolysis of water-insoluble α-acyloxy esters, (±)- 5 and (±)-6, was carried out using lipases immobilized with Celite or a synthetic prepolymer (ENTP-4000 or ENT-4000) in a water-saturated organic solvent to produce chiral intermediates, (2S,3S)-5 and (2S,3R)-4, for the synthesis of diltiazem hydrochloride 1 and (-)-indolmycin 2, respectively. Furthermore, enantioselective hydrolysis of (±)-6 using lipid-lipase aggregates in water-saturated organic solvent was also found to give (2S,3R)- 4.

ENZYMATIC HYDROLYSIS IN ORGANIC SOLVENTS FOR KINETIC RESOLUTION OF WATER-INSOLUBLE α-ACYLOXY ESTERS WITH IMMOBILIZED LIPASES

Asymmetric hydrolysis of water-insoluble α-acyloxy esters, (+/-)-5 and (+/-)-6, was carried out using lipases immobilized with celite or synthetic prepolymer (ENTP-4000 or ENT-4000) in water-saturated organic solvent to produce chiral intermediates, (2S,3