1252638-10-0

Basic information

• Product Name: (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide
• Synonyms: (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide
• CAS NO: 1252638-10-0
• Molecular Weight: 353.829
• Mol File: 1252638-10-0.mol

Chemical Properties

• CAS DataBase Reference: (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide(1252638-10-0)
• EPA Substance Registry System: (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide(1252638-10-0)

Safety Data

• Hazardous Substances Data: 1252638-10-0(Hazardous Substances Data)

Upstream product

• 1252632-24-8 tert-butyl (2S,4R)-4-[(2-chlorophenyl)sulfonyl]-2-{[(1-cyanocyclopropyl)amino]carbonyl}pyrrolidine-1-carboxylate 

Downstream Products

• 1252641-78-3 (4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-{[1-(2,4-dichloro-5-fluorophenyl)cyclopropyl]carbonyl}-L-prolinamide 
• 1252637-13-0 (4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-[(1-phenylcyclopropyl)carbonyl]-L-prolinamide 
• 1268444-76-3 (4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-[(1-phenylcyclobutyl)carbonyl]-L-prolinamide 
• 1252637-12-9 (4R)-1-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-L-prolinamide 
• 1252638-12-2 (4R)-1-{[1-(4-chlorophenyl)cyclobutyl]carbonyl}-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-L-prolinamide 
• 1252638-13-3 (4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-{[1-(3,4-dichlorophenyl)cyclopropyl]carbonyl}-L-prolinamide 
• 1252641-15-8 (4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}carbonyl)-L-prolinamide 
• 1252641-23-8 (4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-{[1-(4-methylphenyl)cyclopropyl]carbonyl}-L-prolinamide 
• 1450978-56-9 tert-butyl 4-(1-((2S,4R)-4-(2-chlorophenylsulfonyl)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine-1-carbonyl)cyclopropyl)piperazine-1-carboxylate 
• 1450978-54-7 (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(1-thiomorpholinocyclopropanecarbonyl)pyrrolidine-2-carboxamide 
• 1450978-52-5 (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(1-(piperidin-1-yl)cyclopropanecarbonyl)pyrrolidine-2-carboxamide 
• 1268444-95-6 (4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-{[1-(2-fluoro-4-iodophenyl)cyclopropyl]carbonyl}-L-prolinamide 
• 1268444-94-5 (4R)-1-{[1-(6-bromopyridin-3-yl)cyclopropyl]carbonyl}-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-L-prolinamide 
• 1268444-93-4 (4R)-1-{[1-(4-bromo-3-fluorophenyl)cyclopropyl]carbonyl}-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-L-prolinamide 

Relevant articles and documents

NOVEL PYRROLIDINE DERIVATIVES

The invention relates to a compound of formula (I) wherein A1 to A3 and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

NOVEL PYRROLIDINE DERIVATIVES

The invention relates to a compound of formula (I) wherein A1 to A3 and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Systematic investigation of halogen bonding in protein-ligand interactions

Halogen bonding triggers activity: Increasing binding affinity was observed for a series of covalent human Cathepsin L inhibitors by exchanging an aryl ring H atom with Cl, Br, and I, which undergo halogen bonding with the C=O group of Gly61 in the S3 pocket of the enzyme. Fluorine, in contrast, strongly avoids halogen bonding (see scheme). The strong distance and angle dependence of halogen bonding was confirmed for biological systems. Copyright