1252644-02-2Relevant academic research and scientific papers
N-Tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B
Kwon, Yoon Jin,Saubern, Simon,MacDonald, James M.,Huang, Xi-Ping,Setola, Vincent,Roth, Bryan L.
scheme or table, p. 5488 - 5490 (2011/01/04)
The serendipitous discovery of N-cyclohexyl-8-fluoro-3,3a,4,9b-tetrahydro- 1H-thiochromeno[4,3-c]isoxazole-1-carboxamide as a selective human serotonin 5-HT2B antagonist with Ki of 42 ± 5 nM is reported herein. A subsequent functional assay indicated little agonist activity compared to 5-HT itself.
