1252651-80-1Relevant articles and documents
Chemical synthesis enables biochemical and antibacterial evaluation of streptolydigin antibiotics
Pronin, Sergey V.,Martinez, Anthony,Kuznedelov, Konstantin,Severinov, Konstantin,Shuman, Howard A.,Kozmin, Sergey A.
, p. 12172 - 12184 (2011/10/04)
Inhibition of bacterial transcription represents an effective and clinically validated anti-infective chemotherapeutic strategy. We describe the evolution of our approach to the streptolydigin class of antibiotics that target bacterial RNA polymerases (RN