1252661-53-2

Basic information

• Product Name: di-tert-butyl (2S,4Z)-4-[(3-methoxyanilino)methylidene]-5-oxopyrrolidine-1,2-dicarboxylate
• CAS NO: 1252661-53-2
• Molecular Weight: 418.49
• Mol File: 1252661-53-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: di-tert-butyl (2S,4Z)-4-[(3-methoxyanilino)methylidene]-5-oxopyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: di-tert-butyl (2S,4Z)-4-[(3-methoxyanilino)methylidene]-5-oxopyrrolidine-1,2-dicarboxylate(1252661-53-2)
• EPA Substance Registry System: di-tert-butyl (2S,4Z)-4-[(3-methoxyanilino)methylidene]-5-oxopyrrolidine-1,2-dicarboxylate(1252661-53-2)

Safety Data

• Hazardous Substances Data: 1252661-53-2(Hazardous Substances Data)

Upstream product

• 27191-09-9 m-anisidine hydrochloride 
• 151121-34-5 di-tert-butyl (2S,4E)-4-[(dimethylamino)methylidene]-5-oxopyrrolidine-1,2-dicarboxylate 
• 35418-16-7 L-t-butyl pyroglutamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 540-88-5 acetic acid tert-butyl ester 

Relevant articles and documents

Parallel solution-phase synthesis of (2S,4E)-4-(arylaminomethylidene) pyroglutamic acids

A library of twelve N(4')-substituted di-tert-butyl (2S,4E)-4- arylaminomethylidene-5-oxopyrrolidine-1,2-dicarboxylates 6/6'a-l were prepared in 47-90% yield by parallel acid-catalysed treatment of di-tert-butyl (2S,4E)-4-[(dimethylamino)methylidene]-5-oxopyrrolidine-1,2-dicarboxylate (4) with anilines 5a - j, ethyl glycinate (5k), and ethyl β-alaninate (31). Acidolytic deprotection of compounds 6a - c, e - j afforded the corresponding (2S,4E)-4-arylaminomethylidene-5-oxopyrrolidine-2-carboxylic acids 7a - c, e - j in 39-99% yield. The configuration around the C=C double bond in the enaminones 6 and 7 was determined by NMR spectroscopy.