1252673-29-2

Basic information

• Product Name: ent-Eletriptan
• Synonyms: ent-Eletriptan;3-[[(2S)-1-Methyl-2-pyrrolidinyl]Methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole;(S)-3-((1-Methylpyrrolidin-2-yl)Methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole
• CAS NO: 1252673-29-2
• Molecular Formula: C₂₂H₂₆N₂O₂S
• Molecular Weight: 381.5111
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 1252673-29-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 613.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.235±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 17.14±0.30(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: ent-Eletriptan(CAS DataBase Reference)
• NIST Chemistry Reference: ent-Eletriptan(1252673-29-2)
• EPA Substance Registry System: ent-Eletriptan(1252673-29-2)

Safety Data

• Hazardous Substances Data: 1252673-29-2(Hazardous Substances Data)

Usage

Uses

An enantiomeric impurity of the serotonin 5-HTIB/ID receptor agonist Eletriptan (E505000).

Relevant articles and documents

SYNTHESIS OF 3--5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE

The present invention refers to the synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole, a drug known by the name Eletriptan, or of its salts. In particular, the present invention regards a process for the synthesis of Eletriptan or of its salt, comprising the following steps: a) Salifying the intermediate of Formula (6), using a dicarboxylic acid to obtain a derived salt; b) Optionally, purifying said raw salt obtained according to step a) by solvent crystallization to obtain a purified salt of the intermediate of Formula (6); c) Converting said salt of the intermediate of formula (6) according to step a) or said purified salt according to step b) into an intermediate of formula (10); d) Converting the intermediate of Formula (10) into Eletriptan or its salt.