1252684-74-4Relevant articles and documents
Lewis base catalyzed enantioselective allylation of α,β- unsaturated aldehydes
Kadlcikova, Aneta,Valterova, Irena,Duchackova, Lucie,Roithova, Jana,Kotora, Martin
, p. 9442 - 9445 (2010)
Being selective: The catalytic allylation of, α,β-unsaturated aldehydes with allyltrichlorosilane in the presence of chiral 3,3′-unsymmetrically substituted bis(tetrahydroisoquinoline) N,N-dioxides was explored. The allylation of various aldehydes proceeded under mild reaction conditions (-78□ °C) with high yields and enantioselectivity (see scheme). This allylation was applied in the synthesis of (S)-(-)-goniothalamin.
