1252684-75-5Relevant academic research and scientific papers
Sequencing cross-metathesis and non-metathesis reactions to rapidly access building blocks for synthesis
Sirasani, Gopal,Paul, Tapas,Andrade, Rodrigo B.
experimental part, p. 2197 - 2205 (2011/04/22)
The olefin cross-metathesis reaction has been sequenced with four common organic transformations in a one- or two-pot manner to rapidly access useful building blocks. Those reactions are: (1) phosphorus-based olefination (e.g., Wittig and Horner-Wadsworth-Emmons); (2) hydride reduction; (3) Evans propionate aldol reaction; (4) Brown allyl- and Roush crotyl-boration. The products of these reactions include stereodefined 2,4-dienoates, trans allylic alcohols, syn-propionate aldols, and chiral non-racemic homoallylic alcohols, respectively. Many of these intermediates have been carried further to natural products, demonstrating the utility of the methodology.
Enantioselective allylation of aldehydes catalyzed by diastereoisomeric bis(tetrahydroisoquinoline) N,N′-dioxides
Vlasana, Klara,Hrdina, Radim,Valterova, Irena,Kotora, Martin
supporting information; experimental part, p. 7040 - 7044 (2011/02/25)
Enantioselective allylation of aromatic and α,β-unsaturated aldehydes with allyltrichlorosilane catalyzed by two diastereoisomeric (R,R ax,R)- and (R,Sax,R)-bis-1,1′-[5,6,7,8-tetrahydro-3- (tetrahydrofuran-2-yl)isoquinoline] N,N′-dio
