125273-96-3Relevant academic research and scientific papers
Synthesis, characterization, DNA binding, DNA cleavage, antioxidant and in vitro cytotoxicity studies of ruthenium(II) complexes containing hydrazone ligands
Mohanraj, Maruthachalam,Ayyannan, Ganesan,Raja, Gunasekaran,Jayabalakrishnan, Chinnasamy
, p. 3545 - 3559 (2016)
The synthesis, spectral characterization, and biological studies of ruthenium(II) hydrazone complexes [RuCl(CO)(PPh3)2L] (where L?=?hydrazone ligands) have been carried out. The hydrazones are monobasic bidentate ligands with O and N
Mechanistic differences between in vitro assays for hydrazone-based small molecule inhibitors of anthrax lethal factor
Hanna, M. Leslie,Tarasow, Theodore M.,Perkins, Julie
, p. 50 - 58 (2008/09/18)
A systematically generated series of hydrazones were analyzed as potential inhibitors of anthrax lethal factor. The hydrazones were screened using one UV-based and two fluorescence-based in vitro assays. The study identified several inhibitors with IC50 values in the micromolar range, and importantly, significant differences in the types of inhibition were observed with the different assays.
