1252798-85-8

Basic information

• Product Name: methyl (5Z,8R,9E)-8-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-10-iodo-5,9-decadienoate
• Synonyms: methyl (5Z,8R,9E)-8-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-10-iodo-5,9-decadienoate
• CAS NO: 1252798-85-8
• Molecular Weight: 562.563
• Mol File: 1252798-85-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (5Z,8R,9E)-8-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-10-iodo-5,9-decadienoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (5Z,8R,9E)-8-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-10-iodo-5,9-decadienoate(1252798-85-8)
• EPA Substance Registry System: methyl (5Z,8R,9E)-8-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-10-iodo-5,9-decadienoate(1252798-85-8)

Safety Data

• Hazardous Substances Data: 1252798-85-8(Hazardous Substances Data)

Upstream product

• 75-47-8 iodoform 
• 93292-50-3 (Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-9-oxo-non-5-enoic acid methyl ester 

Downstream Products

• 1252798-63-2 (5Z,8R,9E)-8-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-10-iodo-5,9-decadienoic acid 

Relevant articles and documents

Protecting-group directed stereoselective intramolecular nozaki-hiyamaKishi reaction: A concise and efficient total synthesis of amphidinolactone A

A convergent; total synthesis of amphidinolactone A, a cytotoxic macrolide from, the cultured dinoflagellate Amphidinium. sp., is described in 13 linear steps. The key step in the synthetic sequence involves an intramolecular NozakiHiyama-Kishi (NHK) reaction for the construction of the 13-membered lactone ring by union of two fragments derived from a single chiral epoxide. The stereochemical outcome of the NHK reaction has been supported by computational studies.