1252798-89-2Relevant academic research and scientific papers
Protecting-group directed stereoselective intramolecular nozaki-hiyamaKishi reaction: A concise and efficient total synthesis of amphidinolactone A
Mohapatra, Debendra K.,Das, Pragna P.,Pattanayak, Manas R.,Gayatri, Gaddamanugu,Narahari Sastry,Yadav
experimental part, p. 4775 - 4784 (2010/10/18)
A convergent; total synthesis of amphidinolactone A, a cytotoxic macrolide from, the cultured dinoflagellate Amphidinium. sp., is described in 13 linear steps. The key step in the synthetic sequence involves an intramolecular NozakiHiyama-Kishi (NHK) reaction for the construction of the 13-membered lactone ring by union of two fragments derived from a single chiral epoxide. The stereochemical outcome of the NHK reaction has been supported by computational studies.
