1252802-33-7

Basic information

• Product Name: 2-1H-indol-3-yl-5-phenyl-1,3,4-thiadiazole
• Synonyms: 2-1H-indol-3-yl-5-phenyl-1,3,4-thiadiazole
• CAS NO: 1252802-33-7
• Molecular Weight: 277.349
• Mol File: 1252802-33-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-1H-indol-3-yl-5-phenyl-1,3,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-1H-indol-3-yl-5-phenyl-1,3,4-thiadiazole(1252802-33-7)
• EPA Substance Registry System: 2-1H-indol-3-yl-5-phenyl-1,3,4-thiadiazole(1252802-33-7)

Safety Data

• Hazardous Substances Data: 1252802-33-7(Hazardous Substances Data)

Upstream product

• 82380-78-7 N¹-benzoyl-N²-(3-indolyl)hydrazine 

Relevant articles and documents

Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazoles

A series of 5-(3-indolyl)-2-substituted-1,3,4-thiadiazoles 5a-m were synthesized and their cytotoxicity analyzed against six human cancer cell lines. The reaction of indole-3-carboxylic acid 3 with aryl or heteroaryl hydrazides afforded the N,N′-diacylhydrazines 4, which upon treatment with Lawesson's reagent resulted in the formation of indolyl-1,3,4-thiadiazoles 5a-m in good yields. Indolyl-1,3,4-thiadiazole 5m with 4-benzyloxy-3-methoxyphenyl and 5-bromo indolyl substituents is the most active in suppressing the growth of cancer cells (IC50 1.5 μM, PaCa2). The compounds 5b, 5e and 5h bearing C-2 substituent as benzyl, 3,4-dimethoxyphenyl and 4-benzyloxy-3- methoxyphenyl, respectively, have shown significant cytotoxicity against multiple cancer cell lines. Introduction of 4-dimethylamino (5d and 5k) and 3,4,5-trimethoxy (5l) groups in the C-2 phenyl ring induced selectivity against MCF7 and MDA-MB-231 cancer cell lines (compounds 5d, 5k and 5l).