1252809-18-9Relevant academic research and scientific papers
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core
Harrington, Paul E.,St. Jean Jr., David J.,Clarine, Jeffrey,Coulter, Thomas S.,Croghan, Michael,Davenport, Adam,Davis, James,Ghiron, Chiara,Hutchinson, Jonathan,Kelly, Michael G.,Lott, Fred,Lu, Jenny Ying-Lin,Martin, David,Morony, Sean,Poon, Steve F.,Portero-Larragueta, Elena,Reagan, Jeff D.,Regal, Kelly A.,Tasker, Andrew,Wang, Minghan,Yang, Yuhua,Yao, Guomin,Zeng, Qingping,Henley III, Charles,Fotsch, Christopher
scheme or table, p. 5544 - 5547 (2010/12/29)
The discovery of a series of novel and orally efficacious type II calcimimetics, developed from the lead compound 1, is described herein. Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model.
