1252879-81-4

Basic information

• Product Name: 1-Benzyl-2-broMoMethyl-pyrrolidine
• Synonyms: 1-Benzyl-2-broMoMethyl-pyrrolidine
• CAS NO: 1252879-81-4
• Molecular Formula: C₁₂H₁₆BrN
• Molecular Weight: 254.16614
• Mol File: 1252879-81-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Benzyl-2-broMoMethyl-pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-2-broMoMethyl-pyrrolidine(1252879-81-4)
• EPA Substance Registry System: 1-Benzyl-2-broMoMethyl-pyrrolidine(1252879-81-4)

Safety Data

• Hazardous Substances Data: 1252879-81-4(Hazardous Substances Data)

Usage

Common uses

Organic synthesis, pharmaceutical research, building block in the synthesis of various pharmaceuticals and bioactive molecules.

Structure

Brominated derivative of pyrrolidine (a five-membered heterocyclic compound) with a benzyl group attached to the nitrogen atom.

Reactivity

Unique structure and reactivity, utilized as a reagent for the preparation of diverse chemical intermediates and functionalized pyrrolidine derivatives.

Safety precautions

Handle with caution, as it may pose certain health hazards, and use in accordance with proper safety protocols.

Upstream product

• 67131-44-6 1-benzyl-2-(hydroxymethyl)pyrrolidine 

Downstream Products

• 1252879-85-8 Br^(1-)*C₁₆H₂₂N₃⁽¹⁺⁾ 
• 1252880-27-5 Br^(1-)*C₁₇H₂₄N₃⁽¹⁺⁾ 
• 1608125-69-4 5-((1-benzylpyrrolidin-2-yl)methoxy)-3-methyl-1-phenyl-1H-pyrazole 

Relevant articles and documents

Structure-activity relationships of pyrazole derivatives as potential therapeutics for immune thrombocytopenias

Idiopathic or immune thrombocytopenia (ITP) is a serious clinical disorder involving the destruction of platelets by macrophages. Small molecule therapeutics are highly sought after to ease the burden on current therapies derived from human sources. Earlier, we discovered that dimers of five-membered heterocycles exhibited potential to inhibit phagocytosis of human RBCs by macrophages. Here, we reveal a structure-activity relationship of the bis-pyrazole class of molecules with -C-C-, -C-N- and -C-O- linkers, and their evaluation as inhibitors of phagocytosis of antibody-opsonized human RBCs as potential therapeutics for ITP. We have uncovered three potential candidates, 37, 47 and 50, all carrying a different linker connecting the two pyrazole moieties. Among these compounds, hydroxypyrazole derivative 50 is the most potent compound with an IC50 of 14 ± 9 μM for inhibiting the phagocytosis of antibody-opsonized human RBCs by macrophages. None of the compounds exhibited significant potential to induce apoptosis in peripheral blood mononuclear cells (PBMCs). Current study has revealed specific functional features, such as up to 2-atom spacer arm and alkyl substitution at one of the N1 positions of the bivalent pyrazole core to be important for the inhibitory activity.

Palladium(II)-N-heterocyclic carbene complexes derived from proline: Synthesis and characterization

Pd(II)-N-heterocyclic carbene complexes derived from proline have been successfully synthesized in good yields and their structures have been characterized by X-ray single crystal diffraction. It was found that the substituents on the N-atom of the pyrrolidine skeleton dramatically affect on the coordination pattern of the palladium complexes. In a word, when an electron-rich group as benzyl group was attached on the N-atom, both of the N-atom and NHC were coordinated to the Pd(II) center; while when an electron-poor group as Ts group was attached, a dimeric mono-coordinated Pd(II)-NHC was obtained exclusively.