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1252883-90-1

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1252883-90-1 Usage

Uses

Tofacitinib impurity P is an impurity of Tofacitinib (T528000), an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases.

Check Digit Verification of cas no

The CAS Registry Mumber 1252883-90-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,2,8,8 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1252883-90:
(9*1)+(8*2)+(7*5)+(6*2)+(5*8)+(4*8)+(3*3)+(2*9)+(1*0)=171
171 % 10 = 1
So 1252883-90-1 is a valid CAS Registry Number.

1252883-90-1Relevant articles and documents

Methyl-α-d-glucopyranoside as Green Ligand for Selective Copper-Catalyzed N-Arylation

Chen, Fengyang,Chen, Guoliang,Chen, Yuanguang,Du, Fangyu,Zhou, Qifan

, p. 4590 - 4600 (2019/12/11)

In the selective N-arylation of amines or azoles with aryl halidesa-, methyl-α-d-glucopyranoside (MG) was found to function as a green ligand of copper powder. In addition, nitrogen heterocyclic amine compounds can also undergo the N-arylation coupling with heterocyclic aryl chlorides. This process allows access to a variety of aromatic amines and aryl azoles under mild reaction conditions, has good tolerance, and proceeds in moderate to high yield.

PIPERIDINE INHIBITORS OF JANUS KINASE 3

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Page/Page column 53, (2010/11/05)

The present invention relates to a new piperidine inhibitors of Janus Kinase 3 activity, pharmaceutical compositions thereof, and methods of use there-of.

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