1252920-47-0Relevant articles and documents
SNAr-based, facile synthesis of a library of benzothiaoxazepine-1,1′-dioxides
Rolfe, Alan,Samarakoon, Thiwanka B.,Klimberg, Sarra V.,Brzozowski, Marek,Neuenswander, Benjamin,Lushington, Gerald H.,Hanson, Paul R.
, p. 850 - 854 (2010)
The construction of a library of benzothiaoxazepine-1,1′-dioxides utilizing a one-pot, SNAr diversification-ODCT50 scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation.