1252935-01-5Relevant academic research and scientific papers
Substituted biaryl pyrazoles as sodium channel blockers
Tyagarajan, Sriram,Chakravarty, Prasun K.,Zhou, Bishan,Taylor, Brett,Fisher, Michael H.,Wyvratt, Mathew J.,Lyons, Kathy,Klatt, Tracy,Li, Xiaohua,Kumar, Sanjeev,Williams, Brande,Felix, John,Priest, Birgit T.,Brochu, Richard M.,Warren, Vivien,Smith, McHardy,Garcia, Maria,Kaczorowski, Gregory J.,Martin, William J.,Abbadie, Catherine,McGowan, Erin,Jochnowitz, Nina,Parsons, William H.
scheme or table, p. 5480 - 5483 (2010/12/24)
Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. A series of low molecular weight biaryl substituted pyrazole carboxamides were identified with good in-vitro potency and in-vivo efficacy. Compound 26, a Nav1.7 blocker has excellent efficacy in the Chung model of neuropathic pain.
