1253046-81-9

Basic information

• Product Name: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-{N-cyclopropyl-N-[(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methyl]amino}-2-propanol
• CAS NO: 1253046-81-9
• Molecular Weight: 510.503
• Mol File: 1253046-81-9.mol

Chemical Properties

• CAS DataBase Reference: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-{N-cyclopropyl-N-[(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methyl]amino}-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-{N-cyclopropyl-N-[(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methyl]amino}-2-propanol(1253046-81-9)
• EPA Substance Registry System: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-{N-cyclopropyl-N-[(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methyl]amino}-2-propanol(1253046-81-9)

Safety Data

• Hazardous Substances Data: 1253046-81-9(Hazardous Substances Data)

Upstream product

• 1203606-39-6 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-cyclopropyl-N-propargylamino)-2-propanol 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Relevant articles and documents

Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase

A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-substituted- 2-propanols (1a-v, 2a-w), which are analogues of fluconazole, have been designed and synthesized as the potential antifungal agents by the click reaction. Click reaction approach toward the synthesis of two sets of novel 1,2,3-triazolyl linked triazole antifungal derivatives 1a-v, 2a-w was achieved by Cu(I)-catalyzed 1,3-dipolar cycloaddition of propargylated intermediate 8 with substituted azidomethyl benzene. The 1,2,3-triazolyl group was inserted into the side chain of the target molecule which can increase the antifungal activity of compounds.