1253059-20-9

Basic information

• Product Name: N,N-bis(4-fluorobenzyl)benzenamine
• Synonyms: N,N-bis(4-fluorobenzyl)benzenamine
• CAS NO: 1253059-20-9
• Molecular Weight: 309.358
• Mol File: 1253059-20-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N,N-bis(4-fluorobenzyl)benzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(4-fluorobenzyl)benzenamine(1253059-20-9)
• EPA Substance Registry System: N,N-bis(4-fluorobenzyl)benzenamine(1253059-20-9)

Safety Data

• Hazardous Substances Data: 1253059-20-9(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 459-46-1 4-Fluorobenzyl bromide 
• 5676-81-3 4-fluorobenzalaniline 
• 459-56-3 4-fluorobenzylic alcohol 
• 98-95-3 nitrobenzene 
• 50-00-0 formaldehyd 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 366-63-2 4-fluoro-N-phenylbenzamide 

Relevant articles and documents

Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C-N Cleavage of N, N-Dibenzylanilines

A visible-light-driven photoredox-catalyzed nonaqueous oxidative C-N cleavage of N,N-dibenzylanilines to 2° amides is reported. Further, we have applied this protocol on 2-(dibenzylamino)benzamide to afford quinazolinones with (NH4)2S2O8 as an additive. Mechanistic studies imply that the reaction might undergo in situ generation of α-amino radical to imine by C-N bond cleavage followed by the addition of superoxide ion to form amides.

MIL-101(Cr) as a synergistic catalyst for the reduction of imines with trichlorosilane

The development of catalyst based on porous crystalline materials (PCM) constructed from metal ions or clusters and multidentate organic ligands is a topic of great interest. In view of the Lewis acidic and basic properties of PCMs, we report for the first time that MIL-101(Cr) works as a synergistic catalyst for the reduction of imines with trichlorosilane as the hydrogen source. Both ketimines and aldimines were tolerated with this protocol, giving the corresponding amines in moderate to high yields. The operational simplicity as well as mild reaction conditions renders this protocol an attractive approach for the synthesis of amines. Furthermore, a chiral MOF, CMIL-101, was also realized by grafting chiral N-formyl proline derivatives to the open metal sites. Moreover, CMIL-101 exhibited a comparable catalytic performance with its homogeneous counterpart in terms of yields and enantioselectivities.

Concise synthesis of aromatic tertiary amines via a double Petasis-borono Mannich reaction of aromatic amines, formaldehyde, and organoboronic acids

A simple and efficient strategy to construct aromatic tertiary amines via a double Petasis-borono Mannich reaction of aromatic amines, formaldehyde, and organoboronic acids has been developed. The transformation provides a useful method for the synthesis of amine derivatives.