1253115-40-0Relevant academic research and scientific papers
Highly enantioselective organocatalytic Michael addition of 2-hydroxy- 1,4-naphthoquinone to β,γ-unsaturated α-oxo esters
Wang, Yi-Feng,Zhang, Wei,Luo, Shu-Ping,Zhang, Guang-Cun,Xia, Ai-Bao,Xu, Xiang-Sheng,Xu, Dan-Qian
, p. 4981 - 4985 (2010)
An organocatalytic enantioselective Michael addition of 2- hydroxy-1,4-naphthoquinone to β,γ-unsaturated α-oxo esters has been developed. The process was promoted by bifunctional chiral amine derived squaramides according to a hydrogen- bonding mediated activation mechanism and af forded the chiral adducts in high yields (up to 88%) and excellent enantioselectivity (up to 98% ee) under mild conditions. This organocatalytic asymmetric Michael addition provides an efficient route toward the synthesis of optically active functionalized naphthoquinones.
